Bruce E. Maryanoff

Bruce Eliot Maryanoff (born February 26, 1947, in Philadelphia, Pennsylvania) is an American medicinal and organic chemist.

Background and contributions

Maryanoff received a B.S. degree in chemistry in 1969, and a Ph.D. degree in organic chemistry in 1972, both from Drexel University.[1] From 1972 to 1974 Maryanoff was a postdoctoral fellow in the Department of Chemistry at Princeton University. He joined McNeil Laboratories, Inc., a Johnson & Johnson subsidiary, in 1974 and advanced on the scientific ladder in various Johnson & Johnson pharmaceutical units to the highest scientific position in the company. Maryanoff retired from Johnson & Johnson Pharmaceutical Research & Development, Spring House, Pennsylvania, in January 2010. He is now affiliated with The Scripps Research Institute, La Jolla, California, the Pennsylvania Drug Discovery Institute (PDDI), Doylestown, Pennsylvania, and the Institute for Hepatitis and Virus Research (IHVR), Doylestown, Pennsylvania, while also serving as Associate Editor for the journal ACS Medicinal Chemistry Letters. He is married to fellow chemist Dr. Cynthia A. Maryanoff.

Maryanoff has been active in the fields of medicinal chemistry and organic chemistry. He is a co-inventor of topiramate,[2] a unique sugar sulfamate drug, which has been marketed worldwide for the treatment of epilepsy and migraine, and has exceeded $2 billion in annual sales.[3] Maryanoff is an internationally renowned expert in drug design and drug discovery, especially in the application of protein structure-based drug design. His drug discovery work led to numerous new chemical entities (NCEs) entering preclinical development, 13 of which advanced into human clinical trials. He made seminal contributions to understanding the stereochemistry and mechanism of the Wittig reaction; adapted the cobalt-catalyzed alkyne trimerization to the synthesis of macrocycles; and devised novel peptides that undergo self-assembly to mimic native collagen structurally and functionally. Maryanoff is an author on 270 scientific publications, including several books (editor), book chapters, and review articles. He is an inventor on nearly 100 U.S. patents, issued or pending, has presented over 160 invited lectures worldwide, and mentored 11 postdoctoral associates. Maryanoff organized and edited a special memorial issue of the Journal of Medicinal Chemistry to honor the memory of Dr. Paul Janssen (2005)[4] and has served on numerous editorial advisory boards for scientific journals and research grant review committees.

Awards and honors

References

  1. ^ NCCE Co-op Hall of Fame Class of 2002–2003, National Commission for Cooperative Education, http://www.co-op.edu/NCCE%20assets/08BOC/site%20pdfs/boc_08_hof/24451_pg78-79.pdf, retrieved 2008-02-26 
  2. ^ US 4513006 , U.S. Patent and Trademark Office, 1985 
  3. ^ TOPAMAX sales in 2006, Johnson & Johnson Annual Report for 2006, http://www.investor.jnj.com/annual-reports.cfm, retrieved 2008-10-17 
  4. ^ Janssen Memorial Issue of J. Med. Chem., American Chemical Society, 2005, http://pubs.acs.org/cgi-bin/sample.cgi/jmcmar/2005/48/i06/pdf/jm040193r.pdf, retrieved 2008-10-17 
  5. ^ 1984 Philadelphia ACS Section Award, Philadelphia Section, American Chemical Society, http://membership.acs.org/p/philadelphia/awards/section_award.html, retrieved 2008-10-17 
  6. ^ AAAS Fellows, AAAS, http://php.aaas.org/about/aaas_fellows/list.php, retrieved 2008-10-14 
  7. ^ Distinguished Chemistry Alumni Award, Drexel University Department of Chemistry, http://www.chemistry.drexel.edu/Dept/ChemDeptAwards.asp#Alumni, retrieved 2008-10-14 
  8. ^ The Philadelphia Organic Chemists' Club Awardees, Philadelphia Organic Chemists' Club, http://www.pocclub.org/POCC_Awards.html, retrieved 2008-10-14 
  9. ^ Johnson Medal Awardees, Johnson & Johnson, http://www.jnj.com/wps/wcm/connect/879c9a004ae70eb5bc50fc0f0a50cff8/johnson-medal-winners.pdf?MOD=AJPERES, retrieved 2008-10-18 
  10. ^ "ACS Honors Heroes Of Chemistry", Chem. Eng. News 78 (36): 50–51, September 4, 2000, http://pubs.acs.org/isubscribe/journals/cen/78/i36/html/7836awar.html, retrieved 2008-10-14 
  11. ^ "2003 ACS National Award Winners", Chem. Eng. News 81 (4): 66–72, January 27, 2003, http://pubs.acs.org/cen/awards/8104/8104awards.html, retrieved 2008-10-14 
  12. ^ NCCE Co-op Hall of Fame Class of 2002–2003, National Commission for Cooperative Education, http://www.co-op.edu/NCCE%20assets/08BOC/site%20pdfs/boc_08_hof/24451_pg78-79.pdf, retrieved 2008-10-17 
  13. ^ "The Drexel 100", Drexel Blue & Gold 17 (1): 24–25, June 15, 2006, http://www.drexel.edu/univrel/new/alumnimagazine/winter_2006.pdf, retrieved 2008-01-12 
  14. ^ ACS MEDI Hall of Fame, ACS Division of Medicinal Chemistry, http://www.acsmedchem.org/maryanoff.html, retrieved 2008-10-14 
  15. ^ ACS MEDI Smissman Award, ACS Division of Medicinal Chemistry, http://wiz2.pharm.wayne.edu/2009smissman.pdf, retrieved 2008-10-17 
  16. ^ ACS Fellows, ACS, http://pubs.acs.org/cen/acsnews/87/8730acs.html, retrieved 2010-10-14 
  17. ^ Prix Paul Ehrlich, SCT, http://www.sct-asso.fr/articles.php?lng=fr&pg=65, retrieved 2010-10-14